Applications For Our Products
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Lab-On-A-Chip

A lab-on-a-chip is a device that integrates one or more laboratory functions on a single integrated circuit (chip).

These chips are just a few millimeters to …

Cell Culturing

In biotechnology, the creation of cell cultures is an important element. This applies to bioreactors that produce biological substances via cells. It is also exciting for systems in cell cultivation.

For example, these systems test the effect of pharmaceuticals…

Liquid-Handling-System

Liquid handling systems form the basis for a wide variety of applications in the life science and medical sectors.

With the mp6 micropump, the components of our partners and the associated software …

Point-of-Care Diagnostik

Point-of-care diagnostics, also called point-of-care testing (POCT), is the performance of diagnostic tests directly

in the hospital ward
in the practice of a registered physician
or a pharmacy …

High-Throughput Screening

High-Throughput Screening (HTS, auch: Hochdurchsatz-Screening) wird vor allem in der Pharmaforschung genutzt.

Bei dieser Art von Test werden an bis zu Millionen von Substanzen biochemische, genetische oder …

High-Throughput Screening

High-throughput screening (HTS, also: high-throughput screening) is used primarily in pharmaceutical research.

In this type of test, biochemical, genetic, or …

Lab-On-A-Chip

Optimization of bioreactors for life sciences

A lab-on-a-chip is a device that integrates one or more laboratory functions on a single integrated circuit (chip). These chips are just a few millimeters to a few square centimeters in size. Despite their small size, they achieve high automation and screening throughput. A lab-on-a-chip can process extremely small volumes of liquid down to less than picoliters. This makes it ideal for microfluidic applications.

Lab-on-a-chip devices enable the functional integration of microfluidics into the diagnostic process. The devices or systems are small and less expensive than large laboratory systems. This allows them to be used directly at the point-of-care or integrated into other, larger systems.

Design of a lab-on-a-chip system

Our mp6 micropump extends passive microfluidic chips and converts them into active units. In microfluidics, we are almost always exposed to laminar flows. This leads to a lack of cross flow within the fluid and makes it difficult to mix two fluids.

In this video, this cross flow is caused by a special structure of the microfluidic chip. This makes it easier to mix the two different colored liquids. The micropump is electronically driven. It enables this slim, small and inexpensive system to fill even the smallest and most complex structures quickly and safely. This is the basis for lab-on-a-chip applications, for example.

Instead of using conventional laboratory technology, tests and diagnoses can be performed directly at the point of care. This saves time and costs and leads to higher system functionality. The flat system can be integrated into portable devices, and digital handling enables variable flow rates and easy operation.

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Case Study: Smart dispensing of liquids in the range of micro- & nanolites

There are a large number of applications where very small quantities of liquids have to be metered. Especially in medicine (e.g. lab-on-a-chip), life sciences and the automotive industry, highly viscous liquids often have to be conveyed at a very low speed. This process must be highly controlled, as deviations are often not easy to detect with the naked eye.

Our team in the microEngineering department at Bartels has made it their business to find a solution to this problem. They took our mp6 micropump and the mp Labtronix lab box and designed a simple setup. In order for you to be successful in the field of nano dispensing, they tested a variety of parameters to find the best ones for this application.

Cell Cultivation

What is an organ-on-a-chip?

An organ-on-a-chip represents a fascinating development in medical research.

This innovative multi-channel 3-D microfluidic biochip not only mimics the complex structure of organs, but also meticulously simulates their diverse activities, mechanisms and physiological responses.

This technological marvel allows researchers to gain profound insights into the functioning of organs and organ systems without relying on living organisms. By creating a kind of artificial organ, the chip opens new avenues for drug discovery, disease modeling and personalized medicine.

Organ-on-a-chip systems promise to revolutionize medical research and improve treatment options for various diseases.

Design of a lab-on-a-chip system

In biotechnology, the creation of cell cultures is an important element. This applies to bioreactors that produce biological substances via cells. It is also exciting for systems in cell cultivation. For example, these systems test the effect of pharmaceuticals.

The cultivation of whole cell lines provides comparable cell material for investigations. In order for the cells to perform their tasks, they must be appropriately supplied in the bioreactors.

A functional organ-on-a-chip in cell cultivation includes

The right temperature
Optimal light conditions and
The supply of nutrients (e.g. glucose) or the addition of growth promoters or inhibitors.

Many tasks in cell cultivation can be performed by automatic pump systems. One advantage here is that these systems are superior to purely manual dosing in terms of quality and convenience. Our mp6 micropumps are placed very close to the reactors. This is possible due to their small size, low energy requirements and long service life. It also makes placement in the incubator easy to set up.

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Cooperation with C-Cit

Our customer C-Cit offers a particularly exciting application here: a pre-assembled flow cell with glucose and/or lactate sensor.

C-Cit Sensors AG has developed a system that measures glucose and/or lactates in a flow cell. This organ-on-a-chip is particularly useful for monitoring cell growth.

The flow cell is the best choice for long-term monitoring in tube-based reactor systems as well as in any perfusion-based bioprocess. Especially since it features a flat bottom with no dead volume. This allows the culture medium to flow through the cell and avoids cell aggregation in or around the sensor. This allows for low-disturbance cell cultivation.

The flow cell housing and cover are made of USP VI certified material. In addition, the flow cell is gamma sterilized. Connected to the C-Cit systems CITSens Bio or CITSens MeMo and the mp6 micropump, the flow cell can be used for media delivery. It can be connected either with Luerlock or with a weldable hose. You can also order a pre-assembled system with an mp6 micropump.

The mp6 micropump takes care of feeding reagents to the sensor in this cell cultivation application. By using a micropump, the entire organ-on-a-chip application remains very small and only small amounts of reagents are needed.

Liquid-Handling-System

What are liquid handling systems for?

Liquid handling systems form the basis for a wide variety of applications in the life science and medical sectors.

With the mp6 micropump, the components of our partners and the associated software made by Bartels, the most diverse systems can be set up and adapted. Particularly advantageous here are the small reagent volumes required and the space-saving design. This saves money and offers you a flexible liquid handling system.

By the way, to make your start in microfluidics easier, we have developed various sets for you. Have a look at our store. We also offer a wide range of microfluidics sets that can help you set up your own system.

Compact liquid handling system

Ultracompact liquid handling is a key advantage of microfluidics.

In collaboration with our partner memetis and with components from Sensirion and microfluidic ChipShop, we have developed this microfluidic dispensing system and flow inverter. Its small and lightweight design is multifunctional, accurate and energy efficient. Watch the video and see how easy to control this liquid handling system.

This liquid handling system is a cost-effective alternative for your liquid control and handling needs. You can customize the system to meet your specific needs, as we supply all the components you need and provide you with easy-to-use software to manage everything.

Moreover, the dispensing system is intelligent, Bluetooth-enabled and 100% tested. So it offers the quality you’ve come to expect from all Bartels components.

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Point-of-care diagnostics

GenSpeed Biotech - Point-of-Care Testing for MRSA & COVID-19

GenSpeed Biotech’s diagnostic system enables point-of-care diagnostics for a wide range of viruses and germs:

The Genspeed product portfolio ranges from COVID19 tests, to TBE antibody tests for general practitioners or pharmacists, to direct detection of periodontitis pathogens in dental practices (dental tests). The system can be quickly and cost-effectively converted to other viruses and germs.

A major advantage over simple rapid tests is that the viral load can also be determined. Thus, not only is it tested whether antigens are present, but also in what quantity they are present. In addition, antibodies can be tested and thus an unrecognized and survived disease or the immune status can be visualized and quantitatively classified.

In the case of, for example, COVID-19 tests, a decision can thus be made as to whether further vaccination is necessary. Thus, a simple point-of-care diagnosis is possible.

Point-of-Care & Bartels

The mp6 micropump is a very important component in this liquid handling system for near-patient laboratory diagnostics.

To display a reliable result, the chip on which the actual antigen test takes place must be filled with both the sample and various liquids. It is essential that the liquids are accurately conveyed to enable accurate test results.

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Point-of-care diagnostics with the mp6

This video shows you how near-patient laboratory diagnostics work, using an ELISA test as an example.

You will see how the mp6 micropump takes passive microfluidic chips and converts them into active units. After the chip is filled with the sample and then a reaction is triggered by two reagents, the individual phases can be optically analyzed by a sensor. The optical analysis can then be digitally and automatically evaluated and documented.

In combination with the electronically controlled mp6 micropump, the slim, small and cost-effective system enables fast and safe filling of even the smallest and most complex structures. Tests and diagnoses can thus be performed directly at the point of care instead of in the laboratory – saving time and costs.

This near-patient laboratory diagnostics can be used decentrally with low turnaround time and high sensitivity and specificity. It enables high-quality testing options that do not necessarily have to be performed by specialist staff.

High-Throughput Screening

Microfluidic solutions for high-throughput screening

High-throughput screening (HTS) is used primarily in pharmaceutical research.

In this type of test, biochemical, genetic or pharmacological tests are performed on up to millions of substances.

High-throughput screening is used primarily to search for new, biologically active substances. This then forms the basis for the development of new drugs.

In HTS, the rule is “You get what you screen for”. This means that extensive molecule libraries are searched, and high-throughput screening is correspondingly time-consuming.

There are high requirements for automation here. This is why robots and automated machines are used for liquid handling. Microfluidics is also used here.

A microfluidic solution for high-throughput screening is droplet generation. Immiscible phases (often oil and water) lead to very small portions that act as microbioreactors and are thus used in high-throughput screening for multiple (multiplexing), parallelized analysis.

Droplet generation with the mp6 micropump

This case study shows how Droplet Generation is possible. We use the mp6 micropump with a pressure sensor, reagents, fluidic accessories and a Droplet Generation chip from our partner microfluidic ChipShop.

The graphic on the right shows you how the system is set up in the case study. To ensure optimal performance, you need to consider some important information.

Learn more about how to generate droplets with our mp6 micropump here.

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Structure of a system for droplet generation

Droplet generation is an important topic in medical technology.

This technology is particularly interesting for the analysis and sorting of single cells as well as for high-throughput screening. In this video we are able to build a small and flexible system. For this we use the micropump mp6 and a chip from our partner microfluidic ChipShop.

Watch the video and learn more about droplet generation:

Applications For Our Products Get Inspired

Lab-On-A-Chip

Cell Culturing

Liquid-Handling-System

Point-of-Care Diagnostik

High-Throughput Screening

High-Throughput Screening

Lab-On-A-Chip

Optimization of bioreactors for life sciences

Design of a lab-on-a-chip system

Case Study: Smart dispensing of liquids in the range of micro- & nanolites

Cell Cultivation

What is an organ-on-a-chip?

Design of a lab-on-a-chip system

Cooperation with C-Cit

Liquid-Handling-System

What are liquid handling systems for?

Compact liquid handling system

Point-of-care diagnostics

GenSpeed Biotech - Point-of-Care Testing for MRSA & COVID-19

Point-of-Care & Bartels

Point-of-care diagnostics with the mp6

High-Throughput Screening

Microfluidic solutions for high-throughput screening

Droplet generation with the mp6 micropump

Structure of a system for droplet generation

Applications For Our Products
Get Inspired